List of Contributors, viii
Preface, xiii
List of Abbreviations, xv
Part 1: History, Epidemiology, and Economics
1 History of Endometriosis: A 20th-Century Disease, 3
Ivo Brosens and Giuseppe Benagiano
2 Endometriosis: Epidemiology, and Etiological Factors, 19
Fabio Parazzini, Paolo Vercellini and Claudio Pelucchi
3 Economic Perspective on Diagnosis and Treatment of Endometriosis, 27
Steven Simoens and Thomas M. D’Hooghe
Part 2: Pathogenesis
4 Pathogenesis: Development of the Female Genital Tract, 35
Jolande A. Land and Johannes L.H. Evers
5 Theories on the Pathogenesis of Endometriosis, 42
Annemiek W. Nap
6 Understanding the Pathogenesis of Endometriosis: Gene Mapping Studies, 54
Jodie N. Painter, Krina T. Zondervan and Grant W. Montgomery
7 Pathogenesis: Epigenetics, 65
Sun-Wei Guo
Part 3: Disease Characterization
8 Endometriosis: Disease Classification and Behavior, 81
G. David Adamson
9 Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities, 92
Jacques Donnez, Olivier Donnez, Jean-Christophe Lousse and Jean Squifflet
10 Extra-abdominal Endometriosis, 108
Antonio Bobbio, Diane Damotte, Anne Gompel and Marco Alifano
Part 4: Biological Basis and Pathophysiology of Endometriosis
11 Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis, 117
Petra A. B. Klemmt and Anna Starzinski-Powitz
12 Stem Cells in Endometriosis, 130
Caroline E. Gargett, Hirotaka Masuda and Gareth C. Weston
13 Role of Steroid Hormones: Estrogen and Endometriosis, 140
Elke Winterhager
14 Role of Steroid Hormones: Progesterone Signaling, 145
Shirin Khanjani, Marwa K. Al-Sabbagh, Luca Fusi and Jan J. Brosens
15 Early Origins of Endometriosis: Role of Endocrine Disrupting Chemicals, 153
Germaine M. Buck Louis
16 Signaling Pathways in Endometriosis (Eutopic/Ectopic), 164
J. Julie Kim and Xunqin Yin
17 MicroRNAs in Endometriosis, 173
M. Louise Hull and Cristin G. Print
18 HOX Genes and Endometriosis, 184
Jennifer L. Kulp, Hakan Cakmak and Hugh S. Taylor
19 Angiogenesis and Endometriosis, 190
Patrick. G. Groothuis
20 Uterine Peristalsis and the Development of Endometriosis and Adenomyosis, 200
Gerhard Leyendecker and Ludwig Wildt
21 Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis, 212
Ian S. Fraser, Natsuko Tokushige, Alison J. Hey-Cunningham, Marina Berbic and Cecilia H. M. Ng
22 Neuroendocrine Aspects of Endometriosis-Associated Pain, 230
Pamela Stratton and Karen J. Berkley
23 Pathophysiology of Infertility in Endometriosis, 240
Bruce A. Lessey and Steven L. Young
24 Inflammation and Endometriosis, 255
Daniela Hornung and Ursula von Wussow
Part 5: Models of Endometriosis
25 Models of Endometriosis: In vitro and In vivo Models, 265
Ruth Grümmer
26 Models of Endometriosis: Animal Models I – Rodent-based Chimeric Models, 270
Kaylon L. Bruner-Tran, Melinda E. McConaha and Kevin G. Osteen
27 Models of Endometriosis: Animal Models II – Non-human Primates, 285
Asgerally T. Fazleabas
Part 6: Diagnosis of Endometriosis
28 Surgical Historical Overview, 295
Ayman Al-Talib and Togas Tulandi
29 Diagnosis of Endometriosis: Imaging, 299
Gerard A. J. Dunselman and Regina G. H. Beets-Tan
30 Diagnosis of Endometriosis: Biomarkers, 309
Beata E. Seeber and Kurt T. Barnhart
31 Diagnosis of Endometriosis: Proteomics, 324
Andrew N. Stephens, Luk J. F. Rombauts and Lois A. Salamonsen
32 Diagnosis of Endometriosis: Transcriptomics, 336
Richard O. Burney and Linda C. Giudice
Part 7: Medical Therapies for Pain
33 Medical Therapies: Randomized Controlled Trials/Traditional Medical Therapies, 343
Neil P. Johnson
34 Medical Therapies: Progestins, 351
Andrew Horne and Hilary O. D. Critchley
35 Medical Therapies: Aromatase Inhibitors, 357
Serdar E. Bulun, Erkut Attar, Bilgin Gurates, You-Hong Chen, Hideki Tokunaga, Diana Monsivais and Mary Ellen Pavone
36 Medical Therapies: Statins, 366
Anna Sokalska and Antoni J. Duleba
Part 8: Surgical Therapies for Pain
37 Surgical Therapies: Principles and Triage in Endometriosis, 387
Alan Lam, Tommaso Bignardi and Su-Yen Khong
38 Surgical Therapies: Peritoneal Endometriosis Surgery, 396
Michael P. Diamond and Valerie I. Shavell
39 Surgical Therapies: Pouch of Douglas and Uterovaginal Pouch Resection for Endometriosis, 402
Maurício S. Abrão, Sérgio Podgaec and Luiz Flávio Cordeiro Fernandes
40 Surgical Therapies: Randomized Controlled Trials in Endometriosis, 410
Jason Abbott
41 Surgical Therapies: Rectal/Bowel Endometriosis, 419
Jim Tsaltas
42 Surgical Therapies: Ureteric Dissection and Urological Endometriosis, 426
Anna Rosamilia and Caroline Dowling
43 Surgical Therapies: Robotics and Endometriosis, 438
Camran Nezhat, Arathi Veeraswamy and Chandhana Paka
Part 9: Infertility and Endometriosis
44 Medical Therapy of Endometriosis: Subfertility, 449
Johannes L. H. Evers
45 Infertility Therapies: The Role of Surgery, 455
Oswald Petrucco and David L. Healy
46 Infertility Therapies: The Role of Assisted Reproductive Technologies, 462
Kimberly Moon, Jeris Cox and Alan DeCherney
47 Ovarian Endometrioma: Surgery and Fertility Preservation, 473
Luk J. F. Rombauts
Part 10: Associated Disorders
48 Endometriosis and Autoimmunity, 485
Srinu Pathivada and Thomas D’Hooghe
49 Endometriosis and Cancer: Epidemiology, 501
Paola Viganò, Edgardo Somigliana, Fabio Parazzini and Paolo Vercellini
50 Molecular Mechanisms Underlying Endometriosis and Endometriosis-Related Cancers, 512
Daniela Dinulescu
51 Pregnancy and Obstetric Outcomes in Women with Endometriosis, 519
Henrik Falconer
52 Sexuality in Endometriosis, 524
Brigitte Leeners
53 Psychosomatic Aspects, 533
Brigitte Leeners
54 Endometriosis in the Adolescent Patient, 548
Claire Templeman
55 Fertility Preservation in Patients with Endometrioma, 555
Jennifer Hirshfeld-Cytron, Candace Tingen and Teresa K. Woodruff
56 Eye to the Future: Research, Diagnostics, and Therapeutics, 560
Peter A.W. Rogers and Gareth C. Weston
Index, 565
The color plate section can be found facing p. 78